About “Patricia A. Jennings”
1991 Ph.D., The Pennsylvania State University
1985 B.A., Rutgers University
Awards and Academic Honors
1997 Sloan Research Fellow
1996 Hellman Faculty Fellow
1991-1994 NIH Postdoctoral Fellow, The Scripps Research Institute
While it is critical for a protein’s structure to be unique and stable, changes in this structure are imperative for binding and catalysis. It is now evident that many protein recognition processes incorporate conformational changes as a requisite event for function. In this manner, protein structure and dynamics are intimately linked with biological activity. We utilize a combination of methods including high resolution multinuclear NMR for solution structure determination, and stopped flow optical, hydrogen/deuterium exchange and mass spectrometric techniques to investigate how protein structure and dynamics are linked with biological activity in solution. Specifically, we are asking: (1) The fundamental question of how amino acid sequence directs protein folding and assembly and (2) What protein/protein interactions are responsible for localization and modulation of signal transduction events?