Improving the understanding of risk, outcomes, and treatment of E. coli infections in people with multimorbidity

The overall aim of this Improving the understanding of risk, outcomes, and treatment of E. coli infections in people with multimorbidity project at University of Dundee is to improve understanding of the interactions between multimorbidity, risk of E. coli infection, antibiotic resistance and adverse outcomes, and the implications for the treatment and prevention of infections.

This  Improving the understanding of risk, outcomes, and treatment of E. coli infections in people with multimorbidity Improving the understanding of risk, outcomes, and treatment of E. coli infections in people with multimorbidity project is offered at University of Dundee University of Dundee .

Context

Risk of E. coli bloodstream infection and associated adverse outcomes are reportedly higher in people with multimorbidity but published reports do not adequately account for physical and/or mental health multimorbidity and frailty. There is limited information about drug-drug and drug-disease interactions in relation to recommended antibiotic therapy for E. coli infection in people with multimorbidity and associated polypharmacy, with implications for clinical policy and practice.

Objectives can be shaped by student’s interest/focus but broadly include to:

• Quantify rates of E. coli bloodstream infection, antibiotic-resistant infection and adverse outcomes in people with/without multimorbidity.

• Examine drug-drug and drug-disease interactions related to antibiotics used for the treatment of E. coli infections in people with multimorbidity and polypharmacy.

• Explore implications for policy and practice.