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Examining the dysfunction of DNA damage repair in synucleinopathies

  • //applyindex.com/wp-content/uploads/2023/11/United-Kingdome.png UK
  • University/Institute Name University of Dundee
  • Attendance Type On Campus (Full Time)
  • Position Duration3 years
  • Position Funding Type PhD Studentship
  • Unspecified Unspecified
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Position Details (PhD Program)

This Examining the dysfunction of DNA damage repair in synucleinopathies project at University of Dundee would build upon determining similarities in nuclear pathology and DNA repair dysfunction in other synucleinopathies such as Parkinson’s disease and multiple systems atrophy.

This  Examining the dysfunction of DNA damage repair in synucleinopathies Examining the dysfunction of DNA damage repair in synucleinopathies project is offered at University of Dundee University of Dundee .

Context

DNA damage is an emerging stressor implicated in the pathogenesis of neurodegenerative diseases. Recent research within post-mortem dementia with Lewy body brain tissue has highlighted the dysregulation of several DNA damage repair pathways, alongside the occurrence of a novel nuclear alpha-synuclein pathology.

This project would delineate

  • the underlying relationship between alpha-synuclein pathology
  • alterations in DNA damage repair and it’s impact on genomic integrity

Research Areas & Fields of Study involved in the position

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