Developing novel targeted therapeutic approaches through induced-proximity of proteins

This Developing novel targeted therapeutic approaches through induced-proximity of proteins project at University of Dundee aims to harness cellular enzymes to target desired post-translational modification on specific intracellular proteins through induced-proximity of enzymes to target proteins.

Through this Developing novel targeted therapeutic approaches through induced-proximity of proteins Developing novel targeted therapeutic approaches through induced-proximity of proteins project at University of Dundee University of Dundee , not only can we understand the function of a specific PTM on target protein but if the targeted PTM alters the protein function in a desired manner, the approach could lead to potential therapeutics. Examples of such approaches include: targeted degradation of proteins through ubiquitylation, alteration of protein function through targeted dephosphorylation, etc.

Student focus

The student will be able to use cutting-edge tools in cell and molecular biology, including CRISPR/Cas9 genome editing, synthetic chemistry, mass-spectrometry and immunofluorescence and learn from world-leading expertise from multiple disciplines at the School of Life Sciences in Dundee.

The student will be able to use cutting-edge tools in cell and molecular biology, including

• CRISPR/Cas9 genome editing

• synthetic chemistry

• mass-spectrometry

• immunofluorescence