Using the metabolome to study aging and geroprotectors in 3D cell models

This project will focus on various aspects of the biology of aging and extending healthspan, including but not limited to cellular metabolic pathways that confer resilience to aging. Learn more at Using the metabolome to study aging and geroprotectors in 3D cell models from the Loughborough University.

Key facts of the  Using the metabolome to study aging and geroprotectors in 3D cell models Using the metabolome to study aging and geroprotectors in 3D cell models programme offered by   Loughborough University Loughborough University

The study of aging, or senescence, is a complex field that seeks to understand the biological processes that lead to the decline in cellular function over time. A novel approach to this research involves measuring volatile organic compounds (VOCs) emitted by cell cultures as they age. These volatiles serve as biomarkers, providing insights into the metabolic changes that occur during aging.

The project in question will utilise cell culture models (BBB, muscle and bone) to simulate the aging process and measure the resulting changes in VOCs. This approach offers several advantages over traditional aging studies. It allows for controlled, replicable conditions and the ability to observe cellular changes in real-time. Moreover, it avoids the ethical and logistical issues associated with human or animal subjects.

One of the key goals of this project is the identification of specific VOCs that correlate with aging. For instance, certain aldehydes increase in concentration as cells age. These aldehydes are byproducts of lipid peroxidation, a process that damages cell membranes and contributes to age-related dysfunction.

The project also explores the reversibility of aging-related VOC changes by introducing geroprotector compounds.

The project is embedded into a larger group of researchers across several Departments within Loughborough including Chemistry, Sport, Exercise and Health Sciences, and Computer Science. You will receive a high level training and mentoring in scientific methods, project design and presentation, and the opportunity to present your findings at international events.

• To obtain additional information about the program, we kindly suggest that you visit the programme website, where you can find further details and relevant resources.