Learning and Memory in the response to recurrent hypoglycaemia in diabetes
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UK
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University of Dundee
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On Campus (Full Time)
3 years-
PhD Studentship
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Unspecified
On Campus (Full Time) Position Details (PhD Program)
This Learning and Memory in the response to recurrent hypoglycaemia in diabetes project is offered at University of Dundee.
In this Learning and Memory in the response to recurrent hypoglycaemia in diabetes Learning and Memory in the response to recurrent hypoglycaemia in diabetes project at University of Dundee University of Dundee , the candidate will test whether this altered response to hypoglycaemia develops through the mechanism of habituation.
Context
Recurrent hypoglycaemia has both acute and chronic consequences and is greatly feared by people with type 1 diabetes. Work from our laboratory over the last few years has revealed that the brain adaptation to recurrent hypoglycaemia in type 1 diabetes represents a specialised form of memory called habituation. Paradoxically this adaptation reduces symptom awareness of hypoglycaemia increasing the risk of severe hypoglycaemia with loss of consciousness.
The project will involve state of the art in vivo techniques including
- hyperinsulinaemic hypoglycaemic clamp studies
- brain microinjection