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Investigations into the protective actions of CBD in the early synaptic deficits in dementia

  • //applyindex.com/wp-content/uploads/2023/11/United-Kingdome.png UK
  • University/Institute Name University of Dundee
  • Attendance Type On Campus (Full Time)
  • Position Duration3 years
  • Position Funding Type PhD Studentship
  • Unspecified Unspecified
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Position Details (PhD Program)

This Investigations into the protective actions of CBD in the early synaptic deficits in dementia project is offered at University of Dundee.

This  Investigations into the protective actions of CBD in the early synaptic deficits in dementia Investigations into the protective actions of CBD in the early synaptic deficits in dementia project at University of Dundee University of Dundee will greatly increase understanding of tau-related synaptic abnormalities, and it will provide valuable insight into the protective effects of CBD against tau-related synaptic dysfunction.

Context

Accumulation of hyper-phosphorylated tau is a key event in Alzheimer’s disease (AD). Aberrant changes in tau cause synaptic abnormalities and cognitive deficits in early AD. Consequently limiting the aberrant effects of tau on synaptic function may prevent the synaptic abnormalities underlying AD-related cognitive deficits.

This study aims to use

  • cell-based models that mirror tau-related synaptic dysfunction

and a combination of

  • electrophysiology
  • immunocytochemistry
  • confocal microscopy

Research Areas & Fields of Study involved in the position

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