Is there a role for Fusobacterium nucelatum, candida or HV16 in oral disease progression

The aim of the this Is there a role for Fusobacterium nucelatum, candida or HV16 in oral disease progression study at University of Dundee would be to determine the possible association between F.nucelatum, candida and HPV16 in oral disease progression by a comparison between normal oral mucosa, benign oral lesions, oral potentially malignant lesions (OPML) and OSCC.

Context of Is there a role for Fusobacterium nucelatum, candida or HV16 in oral disease progression study at University of Dundee

The prognostic impact ofwould be investigated.

Oral squamous cell carcinoma (OSCC) accounts for over 90% of all oral cancers and is generally considered the 8th most common cancer worldwide [1]. Despite therapeutic advances, the 5-year survival rate is approximately 50%, making OSCC one of the most devastating malignancies [1]. Recognised risk factors for OSCC include tobacco and alcohol consumption [1]. However, many patients develop OSCC who lack these risk factors leading to speculation about the role of the oral microbiome in the development of OSCC.

• Inflammation caused by infections has been suggested to be one of the most important preventable causes of cancers in general

• Fusobacterium nucleatum is a commensal of the human oral cavity which is associated with subgingival plaque and poor oral hygiene and has been implicated as a driver of the progression of colorectal carcinoma
• Yeasts, such as Candida, may invade oral epithelium and may also be causally involved in dysplastic changes.