Molecular characterisation of post-tuberculous bronchiectasis

  • //applyindex.com/wp-content/uploads/2023/11/United-Kingdome.png UK
  • University/Institute Name University of Dundee
  • Attendance Type On Campus (Full Time)
  • Position Duration3 years
  • Position Funding Type PhD Studentship
  • Unspecified Unspecified

Position Details (PhD Program)

This Molecular characterisation of post-tuberculous bronchiectasis project is offered at University of Dundee.

In this Molecular characterisation of post-tuberculous bronchiectasis Molecular characterisation of post-tuberculous bronchiectasis project at University of Dundee University of Dundee , the student will investigate the lungs of patients with post-TB bronchiectasis to answer the following clinically relevant questions

  • What is the inflammatory endotype of patients with post-TB bronchiectasis and how does this compare to classical ‘idiopathic’ bronchiectasis
  • What the natural history of post-TB bronchiectasis compared to idiopathic bronchiectasis.

Context

Tuberculosis is a major health problem is Iraq and globally. While treatment of TB, including MDR TB has greatly improved resulting in high rates of clinical cure, many patients with TB are left with persisting lung disease including airflow obstruction and bronchiectasis.

The questions of this project will be addressed by

  • examined neutrophil function using isolation of cells from whole blood
  • microbiome sequencing using 16s rRNA sequencing
  • analysis of pre-existing databases of clinical data.

Research Areas & Fields of Study involved in the position

Position Start Date