Multi-scale image-based characterization of articular cartilage mechanics
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Belgium
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KU Leuven
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On Campus (Full Time)
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Salary or Fellowship for Postdocs
September 29, 2025
On Campus (Full Time) Position Details (Postdoc)
Are you a motivated early-career researcher with a passion for biomechanics, medical imaging, or mechanobiology? Join us in the ERC-funded OA-CONNECT project (PÏ Prof. Ilse Jonkers), where we explore a fundamental question: why does mechanical loading—typically beneficial for cartilage and chondrocyte biology—turn harmful in osteoarthritis (OA)?
Our interdisciplinary team investigates this question across multiple scales, from joint-level movement to molecular cell responses, using a combination of in vitro, in silico, and in vivo methods.
As a postdoctoral researcher, you will focus on advancing dynamic multi-scale imaging techniques to characterize cartilage mechanics in real time. This includes:
• Developing and applying deformation microscopy, high-field MRI, and clinical MRI to capture deformation fields and integrating inverse FE to characterize the mechanical properties.
• Contributing to the development of PET-MRI protocols for simultaneous assessment of molecular responses under mechanical load
These innovations will offer an unprecedented view into cartilage degeneration and its mechanobiological drivers—paving the way for non-invasive, personalized strategies in OA treatment.
This position offers opportunities to:
• Work at the intersection of biomechanics, imaging, and molecular biology
• Collaborate with experts in imaging, modeling, and clinical translation
• Build a strong research profile in a cutting-edge, ERC-funded environment
We are seeking a curious and committed junior postdoctoral researcher eager to contribute to high-impact research and grow within a supportive, interdisciplinary team.
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Responsibilities
As a postdoctoral researcher in the OA-CONNECT project, you will:
- Design, conduct, and analyze experiments to investigate cartilage behavior under mechanical loading.
- Develop and implement advanced imaging workflows, including deformation microscopy, high-field and clinical MRI, and PET-MRI.
- Contribute to the refinement and application of inverse finite element (FE) modeling for multiscale mechanical characterization of cartilage.
- Integrate in vitro, in silico, and in vivo data into a coherent, multi-scale mechanobiological framework.
- Collaborate closely with a multidisciplinary team of engineers, biologists, and clinicians.
- Disseminate research findings through peer-reviewed publications, conference presentations, and scientific outreach.
- Support and mentor graduate students, and help foster a collaborative and inclusive research environment.
Profile
- A PhD in biomedical engineering, biomechanics, biophysics, medical imaging, or a closely related field.
- A solid background in MR imaging, medical image analysis, and experimental biomechanics
- Hands-on experience with one or more of the following techniques is an asset: clinical or high-field MRI, PET-MRI, deformation microscopy, or finite element modeling.
- Demonstrated ability to work effectively across disciplines such as engineering, biology, and clinical research.
- A strong scientific track record, evidenced by peer-reviewed publications and presentations at international conferences.
- A creative and independent research attitude, with excellent problem-solving skills.
- A team-oriented mindset and strong communication skills in English (written and spoken).
Offer
What we offer
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A full-time postdoctoral position for an initial period of one year, with the possibility of extension to a second year based on a positive performance evaluation.
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The opportunity to contribute to a cutting-edge, ERC-funded research project at the intersection of biomechanics, advanced imaging, and computational modeling.
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Access to state-of-the-art imaging infrastructure, including high-field MRI, PET-MRI, and deformation microscopy, as well as advanced computational resources.
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A dynamic, interdisciplinary, and international research environment with strong collaborations across clinical, biological, and engineering domains.
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Active support for your professional development, including mentoring, participation in international conferences, and networking opportunities within the ERC and broader scientific community.
Interested?
For more information please contact Prof. dr. Ilse Jonkers, tel.: +32 16 32 91 05, mail: [email protected] or Mr. Ali Elahi, tel.: +32 16 19 38 98, mail: [email protected].
KU Leuven strives for an inclusive, respectful and socially safe environment. We embrace diversity among individuals and groups as an asset. Open dialogue and differences in perspective are essential for an ambitious research and educational environment. In our commitment to equal opportunity, we recognize the consequences of historical inequalities. We do not accept any form of discrimination based on, but not limited to, gender identity and expression, sexual orientation, age, ethnic or national background, skin colour, religious and philosophical diversity, neurodivergence, employment disability, health, or socioeconomic status. For questions about accessibility or support offered, we are happy to assist you at this email address.