Postdoctoral researcher to develop antisense therapies for familial Alzheimer’s

The Laboratory for the Research of Neurodegenerative Diseases headed by prof. Bart De Strooper in collaboration with the Laboratory for Therapeutic and Diagnostic Antibodies headed by Prof. Maarten Dewilde, is looking for a motivated postdoctoral scientist to join our multidisciplinary project on gene therapy for Alzheimer’s Disease.
The Laboratory for the Research of Neurodegenerative Diseases is a vibrant environment where key issues related to Alzheimer’s disease are tackled and The laboratory of Therapeutic and Diagnostic Antibodies focusses on the generation and characterization of monoclonal antibodies (Mabs), antibody derivatives, nanobodies and diabodies for application as either therapeutics, diagnostics or research tools.

Responsibilities
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This work is focused on the specific targeting of clinical mutations that cause dominant inherited Alzheimer’s disease using a unique antisense strategy (ASO). We will couple those ASO to our proprietary blood-brain shuttles to improve brain exposure, improve administration via intravenous instead of intrathecal routes, and decrease toxicity associated with ASO treatment.
The candidate will be involved in both the generation and the testing of the ASO constructs and will follow the clinical candidates on their journey from preclinical to clinical application.
Additional information may be found in the following selected references:
De Strooper, B. & Karran, E. New precision medicine avenues to the prevention of Alzheimer’s disease from insights into the structure and function of gamma-secretases. EMBO J 43, 887-903 (2024).
Rue, L. et al. Novel Human/Non-Human Primate Cross-Reactive Anti-Transferrin Receptor Nanobodies for Brain Delivery of Biologics. Pharmaceutics 15 (2023).

Profile
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The successful candidate:
Should hold a PhD degree in neuroscience, biology, chemistry, engineering or a related field
Should be creative, enthusiastic, critically thinking, and motivated
Ready to work against stringent deadlines
Enjoys teamwork and has excellent oral and written communication skills in English.
Appreciated
Experience working with laboratory mice (FELASA B)
Project management and effective communication skills
Knowledge of the literature on neurodegenerative disorders
Good understanding of antisense oligonucleotide therapies
Interested in brain delivery of drugs
Good publication record

Offer
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An exceptional strong scientific environment
Possibility to supervise students and technicians and develop an independent research profile
Access to state-of-the-art infrastructure
A stimulating, diverse international world-class research environment
Animal models, expertise in neurodegenerative disorders
Financial support is available for at least 2 years (renewable one year contract). However, the successful candidate is encouraged to obtain a personal fellowship (Marie-Curie, HFSP, EMBO, or National funding organizations).
Start date: as soon as possible – the position is available immediately

More information
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Find out more about the De Strooper lab via this linkFind out more about the Dewilde via this linkInterested in a virtual visit? Take a look inside our lab here

Interested?
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Motivated candidates with a strong interest in neurodegeneration and with a strong commitment to basic research are invited to apply. Please complete the online application procedure and include a CV, a list of publications, a summary of past research and the contact information of 2 to 3 referees. The best-ranked candidates will be invited for an interview.
For additional information concerning this position, please contact Bart De Strooper ([email protected]) or Maarten Dewilde ([email protected])
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