Doctoral Researcher: Gut microbiome metabolism and molecular mechanisms mediating gut microbiome-host interactions?
Position Details (PhD Research Project)
A 3-year Doctoral Researcher position is available at the Department of Biological and Environmental Sciences, University of Jyväskylä, Finland, in the group of Dr. Suvi Ruuskanen. The Doctoral Researcher will work in an ERC-funded project where the overarching aim is to understand the significance of the gut microbiome in thermal adaptations in birds within and across generations, and species.Starting date is April 1, 2026 or as mutually agreed.
PROJECT DESCRIPTION
All animals on our planet carry microorganisms in their gut. The gut microbiome has recently been shown to be strongly linked to health in humans and model animals, and potentially playing a role in adapting to environmental changes. For example, studies in vertebrate and invertebrate model organisms, and our own data on wild birds suggest that the microbiome changes with temperature, and there is proof-of-concept data that this compositional shift in the microbiome occurs as an adaptive response to cold exposure, leading to changes in thermal physiology. However, most data up to date only considers the identities of gut microbes, not their functions and therefore the underlying molecular mechanisms of the microbiome-host communication are less understood. In this project the student will study the functional changes in gut microbiome in response to environmental and host physiological changes, aiming to shed light on the molecular mechanisms mediating host-microbiome interactions. One focus is on metabolomics profiles, and the student is also developing novel measurements on bacterial vesicles and their content in birds. Lots of samples have already been collected from previous experiments, but the student is expected also to contribute to sample and data collection using Japanese quail animal models.
DUTIES
The doctoral researcher position will involve laboratory analyses (most likely metabolomics, bacterial vesicles), conducting data and sample collection on Japanese quails, data analyses, and manuscript preparation and presentations. The exact questions can be tailored following interests of the candidate.
Who we are looking for
Department of Biological and Environmental Science
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University of Jyvaskyla